Isoniazid poisoning in dogs
Isoniazid poisoning is an uncommon case, but all owners should be aware of this poison as much as possible. The peculiarity of the drug is that it is well absorbed into the blood and acts quickly and strongly. Perhaps the intentional poisoning of animals by enemies.
The timely use of a specific antidote will help in time to react to the danger and eliminate the effects of poisoning.
When a dog can get poisoned
Isoniazid (Tubazid) - a drug for the treatment of tuberculosis. Tablets containing it are freely available. They are non-toxic to humans and most animals, but they pose a serious danger to members of the canine family. This is due to the lack of a specific enzyme that destroys the drug. There is evidence that cats also suffer from Isoniazid poisoning, but for them the drug is dangerous in a much higher dosage.
The first sensational cases of the mass death of dogs from Isoniazid refer to 2003. Another scandal broke out in 2010, when the authorities of the Donetsk and Lugansk regions used the drug to combat stray dogs. After a wave of protests from animal defenders, the practice disappeared. To date, isoniazid poisoning in dogs can occur in places where animal haters are activated — the so-called dog-hunters, or if your pet accidentally eats medicines from a home health kit. Poisoners scatter bait with Isoniazid in places of walking, especially advanced add anti-emetic agents to the poison. In this case, the protective reflex of ridding the body of a harmful substance does not work.
Be careful when walking your pet, and if in your area there are reports of poisoned dogs, get in a pharmacy and keep on hand an antidote to Isoniazid - vitamin B6, or Pyridoxine.
Main symptoms of isoniazid dog poisoning
The drug is perfectly absorbed from the stomach and quickly enters the blood. The first symptoms of isoniazid poisoning in dogs occur within 30 minutes after eating the poisoned bait:
- loss of coordination - vacillation, weakness of the legs, the dog "collapses" to the side;
- profuse drooling;
- convulsions caused by metabolic under the action of poison;
- in severe cases, respiratory depression, prolonged seizures, coma, and death.
The cause is metabolic acidosis - a violation of the acid-base balance of the internal environment of the body. With severe poisoning, convulsions are long lasting and are not relieved by anticonvulsants.
First aid and treatment of dogs
The lethal dose of Isoniazid for a dog is 50 mg per pound of live weight. Ordinary human tablets contain 300 mg of the drug. A few pills are enough for even a large dog to die. Therefore, if you have even the slightest suspicion, and the animal has specific signs of poisoning a dog with Isoniazid, immediately inject an antidote to it.
- Antidote: Vitamin B6 (Pyridoxine) is sold in any human pharmacy as a sterile solution for injection (1 or 5%) in 1 ml ampoules, dispensed without a prescription. Injected intravenously at a dose equal to the amount of poison taken. If the amount of Isoniazid is unknown, then Pyridoxine is administered at the rate of 50 mg per kilogram of live weight. Or in the amount of 3-5 grams per animal (that is, from 30 to 50 ml of 1% solution). If it is not possible to do intravenously, colitis intramuscularly. If there are convulsions, then injected within 5 minutes, and in their absence - within half an hour. Convulsions usually disappear after administration, but consciousness may remain confused for some time (several hours).
- Vitamin B6 is non-toxic even in large doses, so there will be no harm from it, even if the suspicion of Isoniazid poisoning is not confirmed.
- Causes vomiting. To do this, use one of the following tools. Hydrogen peroxide 3% solution diluted with water in a 1: 1 ratio, force-fed at the rate of 1 tablespoon per 3 kg of dog weight. A solution of salt or baking soda: 1 teaspoon diluted in a glass of water. It is enough for a medium sized dog to give half a glass, for large breeds 200–250 ml of solution is sucked out. All solutions are made on warm water.
- After the dog vomited, give substances that adsorb the poison. Activated carbon is soldered at the rate of 1–3 grams per kilogram of body weight. Tablets: Enterosgel, Polyphepanum, Enterosorb, Sorbex should be finely crushed and diluted in water. The powder is diluted in water to the state of a kissel and poured 100–200 ml using a syringe into the corner of the mouth.
- Saline laxatives: Glauber's salt, magnesium sulfate, Karlovy Vary salt. You can use the complex saline laxatives for people sold in pharmacies.
- To maintain the functioning of the heart - Corvalol in a dose of 15 drops per 20 kg of weight.
Remember that the gag reflex can not be provoked with severe convulsions and loss of consciousness. It is also useless to induce vomiting and give a laxative, if a long time has passed since taking poison (more than 2 hours).
Take the dog to the vet, the doctor will make intravenous fluids to alleviate the effects of poisoning, prescribe symptomatic treatment, and speed up the elimination of degradation products from the body.
If veterinary care is not available, it is advisable to put an intravenous drip with saline and glucose, or make an injection subcutaneously: 20-40 ml of saline and 5-10 ml of 5% glucose solution. To relieve seizures give Diazepam at a dose of 1 mg per kg of body weight.
If the dog is poisoned with Isoniazid, the symptoms may be similar to signs of poisoning with other poisons. In any case, in the event of unexplained convulsions after possible eating the bait, it is recommended to induce vomiting, give the adsorbent and laxative, and inject vitamin B6. And as quickly as possible, provide your pet with qualified veterinary assistance.
Poisoning, possibly when eating animals any food on the street. Therefore, the best prevention is a well-bred dog. If you have not managed to overcome undesirable food behavior with the help of dog training, then walk your pet on a leash or in a muzzle.