Uniothiol - an antidote for poisoning
When exposed to poisonous substances on the body, a person may feel unwell, or he will have symptoms of poisoning that do not always lead to death, but a fatal outcome in such cases is not excluded.
You can treat poisoning in many ways, and one of them is the use of an antidote - a substance that binds and removes poison from the body. One of these drugs is Uniothiol, an antidote used for various poisonings. Consider how it works and how to use it.
Mechanism of action "Unitiol"
The drug "Unitiol" was developed in the Soviet Union, as an antidote, which helps against the influence of certain toxic chemical substances. You can treat poisoning if:
- prevent the entry of a poison into the body;
- accelerate its removal;
- bind and withdraw it from the body, until the consequences develop.
Prevent the entry of a substance into the body, using methods of prevention, or removing a person from the area of infection. To speed up its deducing the blood liquefaction and the forced diuresis help. This means that a large amount of liquid is injected intravenously, and then it is excreted by stimulating the kidney function, with the poison being excreted along with the urine.
The antidotes or antidotes can bind and remove the poison from the body. They are different for each poison. Uniothiol is a drug that contains two sulfhydryl groups (- SH). By the way, its predecessor the British anti-lyuthitis BAL, developed to combat the poisonous substance lewisite, has only one (-SH) group.
How can Uniothiol, the mechanism of action of which, be associated with active (-SH) groups can help? The sulfhydryl groups Unityol are able to bind heavy metals (mercury, chromium, arsenic, copper, zinc, bismuth and others) that are present in certain drugs, instruments, paints and exhaust gases. Reducing the number of sulfhydryl groups in the blood, when poisonous substances join them, causes pain. This happens with diabetes, amyloidosis, polyneuropathy, caused by chronic alcoholism.
Uniothiol binds heavy metals and releases sulfhydryl blood groups. This relieves pain and allows the recovery of enzymes, the work of which has been disturbed by the presence of heavy metals in the blood. Therefore, it is considered that Uniothiol is an effective antidote for heavy metal poisoning, and it contributes to their elimination.
"Unitiol" is used as an antidote not only for poisoning with heavy metals, but also for poisoning with substances that cause a deficiency of sulfhydryl groups in the body (alcohol).
Application of "Unitiol"
The drug is used for poisoning with heavy metals (with the exception of lead), with diseases that cause polyneuropathy (diabetes mellitus, chronic alcoholism, Wilson-Konovalov's disease), cardiac glycoside poisoning.
Consider how Uniothiol is used as an antidote for poisoning.
Uniothiol in mercury poisoning
Mercury poisoning can occur both at home and at work. Probably, each of you at least once broke glass thermometers to measure body temperature. In addition, mercury is used in galvanic processes, and it is part of some complex devices. When it enters the external environment, mercury evaporates quickly and its vapors are very toxic.
In acute mercury poisoning, "Unitiol" is used to wash the stomach and injected intramuscularly or subcutaneously. Uniothiol forms an insoluble mercaptopide compound with mercury, which is easily eliminated from the body.
"Unitiol" inside is injected during the gastric lavage with a probe. The stomach is washed several times and then 10-15 ml of Uniothiol is injected through the probe, then the stomach is washed again after 10-15 minutes. He is well absorbed into the bloodstream, binds mercury and removes it through the kidneys.
To treat mercury poisoning, Uniothiol is also administered intramuscularly, with a dosage of 0.05 g / kg body weight. On the first day, 3-4 injections are made, in the second 2-3, then 1-2 injections for a week until the symptoms disappear completely.
Uniothiol for arsenic poisoning
Arsenic poisoning occurs when insecticides, herbicides used to control rats, mice, flies and cockroaches, are eaten. In addition, arsenic is used in the production of glass in the pharmaceutical industry.
After its entry into the body can be observed and gastrointestinal and paralytic form of poisoning. Paralytic is characterized by severe weakness, muscle cramps. It quickly leads to a coma and is often fatal.
If the time does not provide medical assistance, acute renal failure develops, which can also lead to death.
"Unitiol" is used as a specific antidote. Since it binds arsenic and removes it from the body. To do this, give him a patient for 1 tablespoon, after which after 5-10 minutes the stomach is washed. The procedure is carried out several times. Intramuscularly it is administered within 3-4 days, in the same dosages as in the case of mercury poisoning. On the first day, 3-4 injections are done, in the second 2-3, then 1-2 times a day until the symptoms disappear completely.
Uniothiol for cardiac glycoside poisoning
Poisoning with cardiac glycosides or digitalis preparations can occur not only in overdose, but also due to cumulation (these drugs have the property of accumulating in the body). Often the cause of poisoning, there is self-medication or the use of herbal decoctions, many cardiac gathers include digitalis, not knowing this person against the background of receiving cardiac glycosides, uses and decoctions. This can lead to poisoning.
"Unitiol" for poisoning with cardiac glycosides is prescribed intramuscularly for 5-10 ml 3-4 times a day, then 1-2 times a day until the symptoms of poisoning disappear.
"Unithiol" in chronic alcoholism
The use of ethyl alcohol and alcohol-containing beverages leads to poisoning of the body, and in some cases to alcoholic coma and death. Therefore, ethyl alcohol can be considered a poisonous substance. Prolonged use of it causes certain changes in the human body and habituation. A person can not stop drinking. Alcohol, getting into the body, decomposes alcohol dehydrogenase to acetaldehyde, it is he that causes intoxication of the body.
"Unitiol" is used in the treatment of alcoholics in conjunction with other drugs. It is not a specific antidote for either alcohol or acetaldehyde, which is the cause of the morning hangover. Although now there are a lot of drugs from the hangover, which contain "Unitiol", applying it from a hangover is unreasonable. And if you take into account the side effects that it causes, it is even contraindicated.
"Unitiol" can be used for chronic alcoholism and during the onset of delirium in a patient. This is a mental disorder, which is accompanied by general excitement, delirium, visual and sound hallucinations.
In such situations, Unitiol is not an antidote. At this point in the body, there is a decrease in the number of sulfhydryl groups, which causes damage and damage to nerve cells, and Unithiol with its two (SH) groups prevents this. It is due to this quality that it is prescribed for diabetes mellitus, when there are disorders of the nervous system, polyneuropathy, reticulopathy.
With chronic alcoholism, "Unitiol" is prescribed in an amount of 3-5 ml 2-3 times a week. And at delirium it is injected once intramuscularly in a volume of 5 ml of a 5% solution.
So, "Unitiol" - a drug that can be used as a specific antidote for poisoning with heavy metals or cardiac glycosides. It is also used to treat chronic alcoholism, delirium, diabetes mellitus in complex therapy.